Change your perspective: how exercise supports cancer treatment | Kylie Moffitt | TEDxWollongong

Kylie Moffitt opens with a patient named David expressing regret about not knowing about exercise oncology earlier in his cancer treatment, setting the stage for her argument about changing perspectives on exercise as medicine. She explains that muscles function as an internal pharmacy, releasing chemical messages when they contract that communicate with the immune system, brain, and other tissues to boost immune defense and reduce inflammation. Despite this biological power, Moffitt identifies that exercise remains one of the hardest treatments for people to adopt because it's wrapped in negative associations and hasn't been properly introduced as medicine.

Moffitt emphasizes that while cancer treatments like chemotherapy and immunotherapy are advancing rapidly, the medical field has focused on attacking the disease while neglecting to prepare the body to survive the treatment. She presents groundbreaking evidence from the 2025 Challenge trial, a major international colon cancer study showing that structured exercise helped people stay cancer-free longer, with researchers describing the benefits as 'drug level.' She notes that despite having this evidence for over a decade and even establishing an exercise studio in a chemotherapy center 10 years ago, pathways for exercise oncology remain underdeveloped.

Through the detailed case study of patient Leanne, Moffitt demonstrates how exercise oncology works in practice. She describes reframing exercise as a 'stimulus' and 'biochemical advantage' rather than traditional exercise, helping patients understand the cellular and physiological responses. Moffitt explains the precise timing and methodology: having Leanne exercise early on chemotherapy days to increase circulation and tumor blood flow, making chemotherapy more effective by opening collapsed tumor vessels and improving oxygen delivery. The exercise also triggers immune system activation, flooding the bloodstream with natural killer cells and creating 'timed immune deployment.' Strength training prepares muscles to absorb treatment toxicities while releasing myokines - signaling molecules that studies show can slow or suppress cancer cell growth. Moffitt concludes by advocating for systematic change through automatic referral from diagnosis to qualified oncology exercise professionals, ensuring everyone has access to this evidence-based medicine rather than treating it as an optional add-on.