Quality Control Test For Containers | Rubber Closures | Good Laboratory Practice | Quality Assurance

The presentation begins with quality control testing for various pharmaceutical packaging materials. For glass containers, the instructor explains four glass types (Type 1-4) and covers essential tests including chemical resistance tests (powdered glass test and water attack test), hydrolytic resistance, light transmission, thermal shock, internal busting pressure, and leakage tests. The powdered glass test involves crushing glass containers, passing through sieves, washing with acetone, autoclaving with water, and titrating with acid to measure alkaline release.

For plastic containers, tests include leakage testing (inversion method and vacuum method), collapsibility testing for tubes, clarity of aqueous extract testing to detect particle release, transparency testing for visual clarity, and eye irritation testing using rabbits. Metal container testing involves filling 50 tubes with ointment, heating and cooling, filtering through metal filter assembly, and counting metal particles under microscope with specific scoring systems.

Rubber closure testing covers residue on evaporation, pH of aqueous extracts, sterility testing in culture media, fragmentation testing using multiple needle punctures, self-sealability testing with methylene blue dye, and penetrability testing to measure force required for needle insertion.

Secondary packaging material testing includes ten different tests: grammage (weight per unit area), thickness measurement, moisture content, folding endurance, bursting strength, water absorption, tear resistance, puncture resistance, box compression testing, and drop testing.

The second half focuses on Good Laboratory Practices (GLP), which are guidelines ensuring quality, reliability, and integrity of non-clinical laboratory studies. GLP covers organizational structure with study directors and management, qualified personnel with proper training, adequate facilities including testing areas and animal care, calibrated equipment with SOPs, and proper handling of test and control articles. The presentation explains protocols for conducting non-clinical studies, including identification codes, study objectives, personnel responsibilities, and experimental design. Record keeping and reporting requirements emphasize accurate documentation, proper storage, and comprehensive final reports. The video concludes with disqualification procedures for testing facilities that fail to comply with GLP standards and reinstatement processes.