How Women Can Improve Their Fertility & Hormone Health | Dr. Natalie Crawford
Dr. Natalie Crawford, a reproductive endocrinologist, discusses actionable steps women can take to improve reproductive and hormone health, covering fertility testing, lifestyle factors, and the relationship between fertility and overall health.
Summary
In this comprehensive discussion, Dr. Natalie Crawford explains how fertility serves as a crucial health marker for women, not just for those wanting children. She emphasizes that infertility is associated with increased rates of metabolic syndrome, cancer, heart disease, and early death due to underlying chronic inflammation. Crawford advocates for proactive fertility testing, particularly the AMH (anti-Müllerian hormone) test, which costs only $79 and measures ovarian reserve, despite current medical guidelines discouraging testing until infertility is diagnosed. She details the biology of egg quality and ovulation cycles, explaining how eggs deteriorate over time due to oxidative stress and metabolic changes. The discussion covers her 'five non-negotiables' for reproductive health: sleep (7-9 hours), stress management, muscle building, anti-inflammatory nutrition, and toxin avoidance. Crawford addresses the impact of various substances on fertility, noting that cannabis use significantly harms sperm quality and increases miscarriage rates, while NSAIDs can prevent ovulation. She discusses birth control effects on fertility, with most forms not causing long-term issues except Depo-Provera. The conversation explores emerging treatments like GLP-1 agonists for endometriosis-related inflammation and supplements like CoQ10 and L-carnitine for egg and sperm quality. Crawford also addresses hormone replacement therapy, arguing for earlier intervention in perimenopause rather than waiting for full menopause diagnosis.
About this episode
Dr. Natalie Crawford, MD, is a double board-certified OB-GYN and reproductive endocrinologist. We discuss how to improve hormone health at any age and the importance of fertility markers not just for pregnancy, but as a powerful window into overall health, vitality and longevity. We discuss hormone replacement therapy, egg freezing, IVF, and what biomarkers like AMH really indicate. Plus, how anti-inflammatory diets and specific supplements can be beneficial and the impact of microplastics and certain fragrances on hormones. We also discuss lesser-known factors that deplete male and female fertility, vitality and health. This conversation highlights how better understanding of hormones and your reproductive markers can empower better informed choices at every stage of life. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Natalie Crawford (00:02:26) Fertility as a Health Marker, Infertility (00:05:34) Perimenopause, Menopause, Hormone Replacement Theory (00:11:01) Sponsors: David & BetterHelp (00:13:35) Hormone Therapy, Extending Ovarian Lifespan (00:19:11) Plastics, Toxins & Fertility (00:22:02) Does Prior Pregnancy Make Conception Easier?, Secondary Infertility (00:29:02) Testing Sperm; Pregnancy Loss & Conceiving Again, Fertility Testing (00:38:17) Sponsor: AG1 (00:39:40) Menstrual Cycle, Egg Number & Quality, AMH Test (00:48:17) Tool: AMH Test; Fertility Education & Patient Choices (00:53:13) Tool: Tracking Ovulation; Ovulation Disorders (00:55:11) AMH Test Cost; Genetic Testing & Patient Choice (01:01:13) Does Egg Freezing Cause Early Menopause?, In Vitro Fertilization (IVF) (01:05:29) Egg Freezing, IVF, Ethical Concerns; Embryo Banking (01:15:21) Sponsor: Eight Sleep (01:16:39) Egg Freezing, Cost & Patient Choices (01:21:22) Concieving After Hormonal Birth Control, IUD or Depo-Provera (01:27:17) Pregnancy Termination & Concieving Again (01:29:28) Support Egg Quality, Tools: Ovulation & Avoiding NSAIDs; 5 Lifestyle Non-Negotiables (01:34:03) Sleep, Melatonin; Cold Plunge (01:38:41) Curcumin, NAD/NR, CoQ10, Supplements for Prenatal Care & Sperm Health (01:42:05) Sponsor: Function (01:43:16) Fertility Research into Supplements & Lifestyle Factors (01:48:21) Inflammation, Red Light (01:53:12) Cannabis & Detriments to Egg & Sperm Health (01:58:57) Nicotine, Smoking, Egg Health & Sperm Count; Healthy Lifestyle Practices (02:02:21) GLP-1s, PCOS, Endometriosis; Human Growth Hormone (02:10:58) Platelet-Rich Plasma; Paternal Age & Sperm Quality; Biotin (02:17:27) Endocrine Disruptors, Fragrances, Receipts, Tool: Fragrance-Free (02:22:48) Patient Education & Empowerment; Inflammation, Celiac Disease (02:25:40) Anti-Inflammatory Diet, Protein, Fiber, Red Meat (02:33:25) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
Key Insights
- Crawford argues that fertility serves as a health marker beyond reproduction, with infertility correlating with increased rates of metabolic syndrome, cancer, and cardiovascular disease
- She advocates that all women should get an AMH test for $79 to assess ovarian reserve, contrary to current medical guidelines that only recommend testing after infertility diagnosis
- Crawford explains that egg quality is determined by genetics and competency, with eggs absorbing 'wear and tear' over time due to oxidative stress and metabolic changes
- She identifies chronic inflammation as a primary enemy of fertility, distinguishing it from necessary acute inflammation required for ovulation
- Crawford reveals that NSAIDs like ibuprofen can prevent follicle rupture and ovulation when taken around ovulation time
- She states that cannabis use significantly damages sperm quality and DNA, leading to higher miscarriage rates in female partners
- Crawford argues that the medical field's approach of making patients 'fail first' before testing is outdated and harmful
- She explains that egg freezing does not deplete ovarian reserve because it only works with eggs already outside the 'vault' that would otherwise die
- Crawford advocates for hormone replacement therapy starting in perimenopause rather than waiting for 12 months without periods
- She identifies sleep as crucial for fertility, with poor sleep doubling infertility rates and affecting hormone production
- Crawford explains that biotin supplementation over 300 micrograms can interfere with hormone lab test accuracy for up to 7 days
- She argues that having been pregnant before provides some statistical advantage for future pregnancies, though secondary infertility is real
- Crawford discusses how endocrine disruptors in everyday products can impact fertility outcomes, particularly with frequent exposure
- She explains that menopause represents ovarian failure and advocates for viewing it as such rather than a natural transition
- Crawford shares her personal experience with pregnancy loss to illustrate how the medical system often dismisses patient concerns and delays appropriate testing
Topics
Transcript
Everybody should get an AMH test. I think it's a very important marker. If you are listening to this and you want kids one day, ask your doctor for this test. It is not a test of egg quality. And we talked about what egg quality is, right? Genetics and egg competency. But it is a check of how many eggs you have. And that knowledge can be really impactful for how you view your future and your plan. Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Natalie Crawford. Dr. Natalie…
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